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Depression — Understanding, Identifying, and Diagnosing | NEJM
In this first episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Dr. Scott-Vernaglia recounts her personal experiences with depression. She and Drs. Sanacora, Crawford, Teel, and Anderson discuss the prevalence of depression and the need to empower the primary care physician to screen for, diagnose, and address suicidality. Available therapies for treatment-resistant depression are briefly introduced and will be explored in greater depth in episode 2 of the miniseries.
For further reading, the following articles, referenced in the video, are available on the Journal’s website: Treatment-Resistant Depression in Older Adults (Steffens, in the February 15, 2024, issue); Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression (Anand et al., in the June 22, 2023, issue); and Electroconvulsive Therapy (Espinoza and Kellner, in the February 17, 2022, issue).
The _New England Journal of Medicine_ is the world’s leading general medical journal. Continuously published for over 200 years, the _Journal_ publishes peer-reviewed research along with interactive clinical content for physicians, educators, and the global medical community at NEJM.org.
#depression #depressionmanagement #mentalhealth #mentalillness #NEJM
Переглядів: 82

Відео

Empagliflozin after Acute Myocardial Infarction | NEJM
Переглядів 2,2 тис.14 годин тому
SGLT2 inhibitors improve cardiovascular outcomes in high-risk patients with diabetes, chronic kidney disease, or heart failure, but their effects after acute myocardial infarction are unknown. Research findings are summarized in a new Quick Take video. To see the full article, follow this link: nej.md/4cEb6EB #cardiology #clinicalmedicine #clinicaltrials #nejm
CAR T-Cells and Safety Signals
Переглядів 33816 годин тому
Source: www.podbean.com/eau/pb-qmivt-15f0cc8 This episode examines CAR T-cell therapy’s early successes, broader promise, and emerging risks, as the FDA considers reports of occasional secondary cancers. A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400701.
How Cluster RCTs Work | NEJM Evidence
Переглядів 85516 годин тому
This Stats, STAT! animated video explores cluster randomized controlled trials and discusses the unique considerations for this trial design. Explore more topics in statistics: evidence.nejm.org/browse/evidence-media-type/stats-stat #statistics #statisticalanalysis #statisticalmethods #clinicaltrials
Adjuvant Pembrolizumab and Survival in Renal-Cell Carcinoma | NEJM
Переглядів 627День тому
Adjuvant pembrolizumab was approved for patients with renal-cell carcinoma on the basis of improvements in disease-free survival observed in the KEYNOTE-564 trial. Data on overall survival are needed. Research findings are summarized in a Quick Take video. To see the full article, follow this link: nej.md/3TVLuKz #oncology #cancerresearch #clinicaltrials #medicalresearch #nejm
Injured, Not Sidelined
Переглядів 29114 днів тому
This season finale examines the moral injury that the current U.S. #healthcare system inflicts on physicians and trainees - and how they may be able to offer care that aligns with their values. A full transcript of this episode is available at www.nejm.org/doi/full/10.1056/NEJMp2400700. View more episodes and subscribe wherever you get your podcasts: www.podbean.com/eau/pb-iyqvi-15e34ce #medica...
How the Pediatric Boards Are Made with Dr. Andrew Dwyer
Переглядів 23214 днів тому
In this episode of Curbside Consults, Dr. Andrew Dwyer, Director of Psychometrics at the American Board of Pediatrics (ABP), joins Mridula Nadamuni, former editorial fellow, to discuss the process of creating and administering pediatric board examinations. Andy Dwyer holds a PhD in educational psychology and an MS in statistics from the University of Nebraska-Lincoln. He is responsible for the ...
From Theory to Therapy: The Evolution of AI in Medicine with Dr. Daphne Koller
Переглядів 37114 днів тому
In this episode of the AI Grand Rounds podcast, Dr. Daphne Koller charts her professional trajectory, tracing her early fascination with computers to her influential role in AI and health care. Initially intrigued by the capacity of computers for decision-making based on theoretical principles, Koller witnessed her niche area - once considered peripheral to AI - grow to dominate the field. Her ...
Nirmatrelvir for Outpatients with Covid-19 | NEJM
Переглядів 1,1 тис.14 днів тому
Nirmatrelvir plus ritonavir reduced the risk of Covid-19-related hospitalization or death in unvaccinated, high-risk adults, but whether it can reduce symptom duration in a broader group is unknown. Research findings are summarized in a new Quick Take video. To see the full article, follow this link: nej.md/49kLhq3 #infectiousdisease #globalhealth #coronavirus #covid19 #nejm
Walking the Dog
Переглядів 36921 день тому
This episode considers what happens when the rigors of training and the pursuit of excellence in in medicine collide with the mental health needs of trainees. A full transcript of this episode is available at www.nejm.org/doi/full/10.1056/NEJMp2400698. Listen and subscribe wherever you get your podcasts: www.podbean.com/eau/pb-xtdeg-15d41cc #medicaleducation #medicine #mentalhealth #nejm
Omitting Axillary Dissection in Breast Cancer | NEJM
Переглядів 1,1 тис.21 день тому
Previous trials have shown that omission of axillary-lymph-node dissection does not appear to affect important outcomes. Research findings extend those findings and are summarized in a Quick Take video. To see the full article, follow this link: nej.md/3PNRGD9 #oncology #breastcancer #nejm
Building Up without Breaking Down
Переглядів 29028 днів тому
This episode asks how medical educators should navigate between demanding intense commitment and hard-won excellence from trainees and seriously threatening their well-being. A full transcript of this episode is available at www.nejm.org/doi/full/10.1056/NEJMp2400697. Source from this episode: www.culturalcomplications.com/ Listen to more episodes and subscribe: not-otherwise-specified-podcast....
Progress for Parkinson's?
Переглядів 36328 днів тому
This episode explores the fastest-growing neurologic condition in the world, Parkinson’s disease. What have we learned in recent years, and where are the greatest hopes for the future? A full transcript of this episode is available at www.nejm.org/doi/full/10.1056/NEJMp2414003. Listen to more episodes and subscribe to Intention to Treat: intention-to-treat-podcast.nejm.org/ #parkinsons #parkins...
What Is Rheumatoid Arthritis? | NEJM
Переглядів 14 тис.28 днів тому
In this Double Take video from the New England Journal of Medicine, Drs. Schubach, Gravallese, and Firestein review the epidemiology, clinical features, pathogenesis, and diagnostic evaluation of rheumatoid arthritis. The video also explores available therapeutic approaches to the disease, including strategies to manage flares. For further reading, the following Review Article, referenced in th...
Ribociclib in Early Breast Cancer | NEJM
Переглядів 841Місяць тому
Ribociclib in Early Breast Cancer | NEJM
Iptacopan for Paroxysmal Nocturnal Hemoglobinuria | NEJM
Переглядів 1,3 тис.Місяць тому
Iptacopan for Paroxysmal Nocturnal Hemoglobinuria | NEJM
Alzheimer’s Disease - Managing Stages of Dementia | NEJM
Переглядів 13 тис.Місяць тому
Alzheimer’s Disease - Managing Stages of Dementia | NEJM
Whatever It Takes
Переглядів 249Місяць тому
Whatever It Takes
From Single Neurons to AI Systems: The Evolution of Decision Sciences in Medicine
Переглядів 417Місяць тому
From Single Neurons to AI Systems: The Evolution of Decision Sciences in Medicine
Omalizumab for Multiple Food Allergies | NEJM
Переглядів 1,4 тис.Місяць тому
Omalizumab for Multiple Food Allergies | NEJM
Debt Et Cetera
Переглядів 186Місяць тому
Debt Et Cetera
Doctors and Guns
Переглядів 164Місяць тому
Doctors and Guns
Enfortumab Vedotin-Pembrolizumab in Advanced Urothelial Cancer | NEJM
Переглядів 1,1 тис.Місяць тому
Enfortumab Vedotin-Pembrolizumab in Advanced Urothelial Cancer | NEJM
OK, Boomer
Переглядів 337Місяць тому
OK, Boomer
Alzheimer’s Disease - Anti-Amyloid Medications, Early Detection, and Screening | NEJM
Переглядів 50 тис.Місяць тому
Alzheimer’s Disease - Anti-Amyloid Medications, Early Detection, and Screening | NEJM
How Treatment Effect Heterogeneity Works | NEJM Evidence
Переглядів 2,7 тис.Місяць тому
How Treatment Effect Heterogeneity Works | NEJM Evidence
Biomarker Changes Preceding Alzheimer’s Disease | NEJM
Переглядів 2 тис.2 місяці тому
Biomarker Changes Preceding Alzheimer’s Disease | NEJM
Race Relations and the First Paramedics
Переглядів 2862 місяці тому
Race Relations and the First Paramedics
Medical Mystery Solved - The Road Less Traveled | NEJM
Переглядів 12 тис.2 місяці тому
Medical Mystery Solved - The Road Less Traveled | NEJM
E-Cigarettes for Smoking Cessation | NEJM
Переглядів 2,1 тис.2 місяці тому
E-Cigarettes for Smoking Cessation | NEJM

КОМЕНТАРІ

  • @MsKlamar
    @MsKlamar 5 годин тому

    Standard medical care includes thrombolysis? K. Rizos MD Athens Greece

  • @Streetdoc72
    @Streetdoc72 9 годин тому

    I’m having it done in 2 days. Wish me luck!

  • @user-sl7iBuilt
    @user-sl7iBuilt 13 годин тому

    Currently on about week 6 of having this. Honestly it’s pure hell, losted my job cause of it, can’t really do anything other than kill time wasting away and cause your head gets starved off blood a lot I’ve passed out a good few times getting hurt. It’s hard to stop negative thinking patterns developing aswell being ill so long.

  • @maysamir1606
    @maysamir1606 День тому

    ❤️

  • @RahulArora-zx8es
    @RahulArora-zx8es День тому

    What will happen if carboprost given iv instead of im

  • @lindacoffin5110
    @lindacoffin5110 День тому

    helpful

  • @user-vj6bs4dm3m
    @user-vj6bs4dm3m День тому

    I knew there had to be other people that can do this.

  • @moefuzz5909
    @moefuzz5909 2 дні тому

    Drill any new holes lately?

  • @robprzybysz
    @robprzybysz 2 дні тому

    ☘️

  • @valenlevalenle6394
    @valenlevalenle6394 3 дні тому

    My husband currently has whooping cough and it is absolute misery! He hasn’t been able to work or do the things he enjoys and he particularly hasn’t been able to sleep because it’s worse at night. He also has asthma so he is truly suffering. I’m hoping he gets better soon as I hate seeing him in pain 😢💔❤️‍🩹😔

  • @zuneid375
    @zuneid375 3 дні тому

    Very useful video ❤

  • @OverchargeOSC
    @OverchargeOSC 3 дні тому

    I’m burning everything I cook

  • @rosibelmurillo2843
    @rosibelmurillo2843 3 дні тому

    Porque se hace eso de verdad no comprendo me pueden explicar porque sucede

  • @bambiehayes-brown1291
    @bambiehayes-brown1291 4 дні тому

    Whooping coughs be like coughing up blood 😨

  • @karenimran3349
    @karenimran3349 4 дні тому

    I have a ground glass lung nodule 6mm and have never smoked. It hasn’t showed up as cancer on the pet scan thank goodness.

  • @pixelmasque
    @pixelmasque 4 дні тому

    Go carnivore, you will fix it

  • @MrAnonymousme10
    @MrAnonymousme10 4 дні тому

    Is the dude even alive as this point?

  • @Veganism_is_death-vh2un
    @Veganism_is_death-vh2un 4 дні тому

    I only took 2 and already feel like a zombie.

  • @DanielC-ck2ds
    @DanielC-ck2ds 5 днів тому

    superb video!!! please make more

  • @georgenauert9370
    @georgenauert9370 5 днів тому

    He might have done something good back in the day, but I still don't trust fauci.

  • @tompartyka352
    @tompartyka352 5 днів тому

    Had an ablation in 2018 after feeling tired etc. Lasted till January 2024. Had 2nd ablation on April 22,2024, both groins went up. Was still in afib, stayed over night, had a cardio version ( shock treatment) and I’m in sinus rhythm. I’m learning this key things for afib. 1- being overweight 2- alcohol use- wine for me 3- eat small meals 4- watch salty foods 5- stay hydrated

  • @adithyavikram7
    @adithyavikram7 5 днів тому

    Role of intraventricular car t cell therapy in recurrent glioblastoma

  • @xamtra
    @xamtra 5 днів тому

    Is that person alive?

  • @kimberlyhaas1
    @kimberlyhaas1 5 днів тому

    sad thing is he can not help it and hes not being dramatic! your body takes over while your mind worries. You are totally helpless in this situation.

  • @EddieMcclanahan
    @EddieMcclanahan 5 днів тому

    A month supply of 30 pills cost $3,700 or more here in the USA as of 2024.

  • @Stalkers-Get-A-Life
    @Stalkers-Get-A-Life 5 днів тому

    That’s Incredibly Disgusting 🤮

  • @mariobonilla4960
    @mariobonilla4960 5 днів тому

    Thank you, NEJM.

  • @periwinklepaula
    @periwinklepaula 6 днів тому

    That's gross!

  • @22pchelka
    @22pchelka 6 днів тому

    Im pregnant and I have this cough😢😢

  • @MFDElk
    @MFDElk 6 днів тому

    Another useful tool in the biostatistics toolbox :)

  • @adithyavikram7
    @adithyavikram7 6 днів тому

    Respected professor when usually you start Sglt2 inhibitors in your practice in a patient with acute mi , like immediately or after 24 hours or after 72 hours or during discharge, when you want to prefer the Sglt2 inhibitor professor, thank you in anticipation.

  • @1998topornik
    @1998topornik 6 днів тому

    His nostrils host the whole party!

  • @kevinbowrin8385
    @kevinbowrin8385 6 днів тому

    Hopefully using CRISPR-Cas9 to engineer the CAR T-Cells will reduce the risk of secondary cancers.

  • @ShuhPond
    @ShuhPond 6 днів тому

    I did not know barium could harden like that. Is this a result of the patient not drinking enough following the series?

  • @YuriyKurnat
    @YuriyKurnat 7 днів тому

    Very good 🎉👏👍👋

  • @naggedd
    @naggedd 7 днів тому

    Wooooooo!

  • @RadagonTheRed
    @RadagonTheRed 7 днів тому

    I can do this! I always assumed that everyone could but apparently it’s only we select few! #TeamNystagmus

  • @TheBoringFamily
    @TheBoringFamily 7 днів тому

    everytime i g̵̡̛̩͈̤͍̰̱͖̱̦̩̖̃̀̊͊̿͋͂̏̈́͋̑́̆̿̐͑͐̊̓̇̽͑͂̒̊̑̄͑̋̋̆̈̃̉͐͊̊̐̾͘͘͜͝͝͠ų̷͉̥͓͉̍̆̒̊̉͌̈͌̏̌̆͒̉̈́̂̈́̓̇̽̓͋͒̀͂̾͒̉̃̋̍̋̎͒̈́̇̈́̊͐͘͜͝l̷̳̭̀̄͌̽͑́̂̚͜͝͝ṕ̴̢̡̟̟̰̱̫͙̜̦̩̪̯̺̮͇͚̟̙͖͇͖̥͓̟̬̣̘͖͙͔̳͍̲̜̫̦͈̫̗͈̝̱͐̈́̍̉̈͛̌́̅̋̆͑̐́̋̿͂̉̈́̄̓̋̐͋̐͂̂̌̉̕̕͘͜͝͝͝͠ͅ my eardrum just did thís. I don't exactly know why.

  • @tee1475
    @tee1475 8 днів тому

    Hey that is so rude

  • @danielasutherna8191
    @danielasutherna8191 8 днів тому

    I want to appreciate Dr Madida on UA-cam for treating my Dad of his Multiple sclerosis and parkinson disease with their natural meds🌿💊🌿🌿

  • @LillyAula
    @LillyAula 8 днів тому

    🎯 Key Takeaways for quick navigation: 00:07 *🦴 Características generales de la artritis reumatoide* - La artritis reumatoide es una enfermedad autoinmune inflamatoria común. - Los pacientes suelen presentar poliartritis simétrica de manos y pies. - La rigidez matinal prolongada es un síntoma distintivo, y las mujeres tienen una mayor prevalencia que los hombres. 01:10 *🔬 Diagnóstico y clasificación de la artritis reumatoide* - El diagnóstico se basa en la evaluación clínica, incluyendo la presencia de artritis en múltiples articulaciones. - Se utilizan pruebas de laboratorio para clasificar en seropositiva o seronegativa. - La seropositividad está asociada con mayor gravedad y mayor probabilidad de requerir cirugía de reemplazo articular. 03:13 *🔍 Fases preclínicas y factores de riesgo de la artritis reumatoide* - La fase preclínica puede durar años antes de la manifestación clínica. - Los factores genéticos y ambientales, como la exposición al tabaco, aumentan el riesgo. - Las infecciones virales pueden desencadenar la activación del sistema inmunológico en individuos genéticamente susceptibles. 04:12 *🧬 Patogénesis de la artritis reumatoide* - La citrulinación de proteínas desencadena la producción de autoanticuerpos. - La inflamación sinovial, mediada por citoquinas proinflamatorias, conduce a la destrucción articular. - La formación de pannus y la activación del sistema del complemento perpetúan la inflamación crónica. 05:43 *💊 Manejo y tratamiento de la artritis reumatoide* - El tratamiento se basa en el control de la inflamación y la prevención del daño articular. - Se utilizan fármacos modificadores de la enfermedad, biológicos y sintéticos dirigidos. - La estrategia "tratar al objetivo" busca alcanzar y mantener la remisión o baja actividad de la enfermedad. 10:52 *📈 Evaluación y seguimiento de la artritis reumatoide* - Se utilizan escalas de actividad de la enfermedad para guiar el tratamiento. - Se busca la remisión como objetivo terapéutico. - La respuesta al tratamiento puede requerir ajustes basados en la evolución clínica del paciente. Made with HARPA AI

  • @mpowellvlogs
    @mpowellvlogs 8 днів тому

    I'm just recovering from it now, one of the worst things I've had its horrible and lasts for ages!

  • @tarkello4267
    @tarkello4267 9 днів тому

    Hear from distractible, thanks Wade

  • @leplattefamily3012
    @leplattefamily3012 9 днів тому

    Thank you for this

  • @charlesclintonmd
    @charlesclintonmd 9 днів тому

    I would like to become an editorial fellow. What I bring to the table: cardiology residency experience from my hometown Costa Rica, multiple additional medically related experiences in most places a Dr could work at, and current Internal Medicine residency training to be completed as of July 2025 in Savannah, GA. I love to critically appraise literature and have trained on this through two different residency experiences. I also love how NEJM presents the data, it's always so refreshing and enjoyable to stumble upon an NEJM article. Where do I apply, and can I live in the Boston area with this salary without having to ask for a loan? Thank you!

  • @nikhilera738
    @nikhilera738 10 днів тому

    But what about safety issues, does risk benefit favour the use of pembrolizumab?

  • @SalmanKhan-wo7lk
    @SalmanKhan-wo7lk 10 днів тому

    Iska treatment Kya Hai 😢😢

  • @kimsherlock8969
    @kimsherlock8969 10 днів тому

    It is now time to allow 😌 those whom dont want to survive without cognition to choose to go in dignity. The disease is fast growing in too many people over 60 years Boomers A parent may live on 94 and non compos mentos 😮 I hope I have a choice of dignity and surrender my dead mind with a living heart to rest in peace

  • @gissie391
    @gissie391 10 днів тому

    It would be great if drs stopped giving us neuroleptics unecessarily .

  • @parkerharrison3024
    @parkerharrison3024 10 днів тому

    Omg im going to hell, but hopefully this man is a ok 😂.